منابع مشابه
Epigenetic alterations in aging.
Aging is a multifaceted process characterized by genetic and epigenetic changes in the genome. The genetic component of aging received initially all of the attention. Telomere attrition and accumulation of mutations due to a progressive deficiency in the repair of DNA damage with age remain leading causes of genomic instability. However, epigenetic mechanisms have now emerged as key contributor...
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Parathyroid cancers (PCas) are rare malignancies representing approximately 0.005% of all cancers. PCas are a rare cause of primary hyperparathyroidism, which is the third most common endocrine disease, mainly related to parathyroid benign tumors. About 90% of PCas are hormonally active hypersecreting parathormone (PTH); consequently patients present with complications of severe hypercalcemia. ...
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Epigenetic mechanisms, acting via chromatin organization, fix in time and space different transcriptional programs and contribute to the quality, stability, and heritability of cell-specific transcription programs. In the last years, great advances have been made in our understanding of mechanisms by which this occurs in normal subjects. However, only a small part of the complete picture has be...
متن کاملEpigenetic Alterations in Alzheimer’s Disease
Alzheimer's disease (AD) is the major cause of dementia in Western societies. It progresses asymptomatically during decades before being belatedly diagnosed when therapeutic strategies have become unviable. Although several genetic alterations have been associated with AD, the vast majority of AD cases do not show strong genetic underpinnings and are thus considered a consequence of non-genetic...
متن کاملHIGHLIGHTED TOPIC Epigenetics in Health and Disease Epigenetic alterations in aging
Gonzalo S. Epigenetic alterations in aging. J Appl Physiol 109: 586–597, 2010. First published May 6, 2010; doi:10.1152/japplphysiol.00238.2010.—Aging is a multifaceted process characterized by genetic and epigenetic changes in the genome. The genetic component of aging received initially all of the attention. Telomere attrition and accumulation of mutations due to a progressive deficiency in t...
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ژورنال
عنوان ژورنال: Journal of Applied Physiology
سال: 2010
ISSN: 8750-7587,1522-1601
DOI: 10.1152/japplphysiol.00238.2010